Allergy Research Group - Pregnenolone 50mg Matrice Lipidique Micronisée 60 Comprimés Entaillés

Works as expect but how can you tell?

I'm trying to figure out what supplements will support my energy and well-being in a menopause. This brand gave me terrible insomnia. Another brand of pregnenolone worked very well though.

I will not repurchase as one of its other ingredients is Maganesium Stearate.

Using this every day for years for interstitial cystitis

DANGERSOUS!!! Not just this brand but all brands of pregnenolone. Before rushing in to take this, best read this as this is what has happened to me. I trusted my NP to know what she was doing, and failed to research this as I should...my mistake. If your body metabolizes ANYTHING slowly right on down to advil, you need to avoid this hormone at all costs (as well as many others). Pregnenolone is at the top of the hormonal cascade meaning that everything is made from it as far as steroidal hormones (testosterone, aldosterone, cortisol, & DHEA.. Estradiol & progesterone synthesis is impaired without a uterus and ovaries. Pregnenolone is also a GABA (one of the "feel good" neurotransmitters) antagonist which means that GABA cannot bind to the receptor sites because of the pregnenolone. My experience with this has been a nightmare. I first took it approximately 3 months ago at half dosage, without any side effects (nor did I notice any benefit!). About 5 weeks ago, I noticed that something was very wrong, fear of driving (never had it in my life), feeling overwhelmed, depressed, anxious and unable to sleep. Not realizing what it was, I thought it was a bit more stress in my life. Not true! Then came the onset of severe palpitations, extreme terror and inability to function coupled with extreme agitation and anger, sensory overload and thoughts of imminent death. Bottom line, I am awaiting results of wearing a holter heart monitor to see how much damage this has done to my heart, praying that it will return to normal and I won't have to have some very serious interventions. So, do your research on this hormone BEFORE you let anyone talk you into taking it...it does not always do what it should with everyone. One online proponent of it years ago has radically changed his tune in recent months as to how much of this substance most people should take. His recommendation? 1-3 mgs with holidays from it. Your liver is in place to protect you from this type of thing, this particular brand is micronized and made lipid soluble so that it avoids the liver on the first pass and goes directly to the blood stream. (Read the label). This in and of itself is highly dangerous for a substance like this.